A two-site phosphorylation cycle, where phosphorylation is catalyzed by the same kinase at both sites and dephosphorylation is catalyzed by the same phosphatase at both sites [Feliu, Wiuf].
i1 : twoSiteModificationG() o1 = S_0+E-->X_1 X_1-->S_0+E X_1-->E+S_1 E+S_1-->X_2 X_2-->E+S_1 X_2-->E+S_2 S_1+F-->Y_1 Y_1-->S_1+F Y_1-->S_0+F S_2+F-->Y_2 Y_2-->S_1+F Y_2-->S_2+F o1 : ReactionNetwork |
In the motif Two-site Modification G, the symbols used in the chemical reactions have the following meaning:
S_i and P_i are substrates with i = 0, 1, 2 phosphorylated sites, E is a kinase and F is a phosphotase, X and Y are the intermediate complexes formed by the enzymes E and F, respectively.
To rename species, use substitute(ReactionNetwork,List).
The object twoSiteModificationG is a method function.